Gabbr1 ELISA Kit for Mouse(Mus musculus) | EIAab.comGabbr1 ELISA Kit for Mouse(Mus musculus)

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Gabbr1 (Gene name),

Gamma-aminobutyric acid type B receptor subunit 1 (Protein name ), GABR1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Gabbr1;

Protein name:

Gamma-aminobutyric acid type B receptor subunit 1(GABA-B receptor 1;GABA-B-R1;GABA-BR1;GABABR1;Gb1);

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with the leucine zipper of the C-terminal bZIP domain of ATF4 via its C-terminal region (By similarity). Interacts with JAKMIP1.

Function:

Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.

Subcellular Location:

Cell membrane Multi-pass membrane protein Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane (By similarity). Colocalizes with ATF4 in hippocampal neuron dendritic membranes.

Protein Attributes:

Sequence length:

960

Sequence:

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960:

DGSRVHLLYK |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:54393

String:

Q9WV18

Pfam:

PF00003

STRING:

10090.ENSMUSP00000025338

UniGene:

Mm.32191

SMR:

Q9WV18

Uniprot:

Q9WV18

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ELISA Kit for Mouse GABA-B receptor 1

Cat.:

E2151h

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Manual:

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96T

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ELISA Kit for Mouse GABA-B receptor 1

Cat.:

E2151r

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Packing:

96T

ELISA Kit for Mouse GABA-B receptor 1

Cat.:

E2151m

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96T

CLIA Kit for Mouse GABA-B receptor 1

Cat.:

U2151m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse GABA-B receptor 1

Cat.:

U2151r

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MSDS:

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Packing:

96T

CLIA Kit for Mouse GABA-B receptor 1

Cat.:

U2151h

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Packing:

96T

Polyclonal Antibody for Mouse GABA-B receptor 1

Cat.:

P2151Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse GABA-B receptor 1

Cat.:

P2151Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse GABA-B receptor 1

Cat.:

P2151Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse GABA-B receptor 1

Protein for Mouse GABA-B receptor 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor."
Sullivan R. , Chateauneuf A. , Coulombe N. , Kolakowski L.F. Jr. , Johnson M.P. , Hebert T.E. , Ethier N. , Belley M. , Metters K. , Abramovitz M. , O'Neill G.P. , Ng G.Y.K.
J. Pharmacol. Exp. Ther.293:460-467(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A);FUNCTION;INTERACTION WITH GABBR2;SUBCELLULAR LOCATION
2.

"The murine GABA(B) receptor 1: cDNA cloning, tissue distribution, structure of the Gabbr1 gene, and mapping to chromosome 17."
Lamp K. , Humeny A. , Nikolic Z. , Imai K. , Adamski J. , Schiebel K. , Becker C.M.
Cytogenet. Cell Genet.92:116-121(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A AND 1B);TISSUE SPECIFICITY
3.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1A AND 1B)
strain: C57BL/6.
tissue: Brain.
5.

"Role of heteromer formation in GABAB receptor function."
Kuner R. , Koehr G. , Gruenewald S. , Eisenhardt G. , Bach A. , Kornau H.-C.
Science283:74-77(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GABBR2
6.

"Marlin-1, a novel RNA-binding protein associates with GABA receptors."
Couve A. , Restituito S. , Brandon J.M. , Charles K.J. , Bawagan H. , Freeman K.B. , Pangalos M.N. , Calver A.R. , Moss S.J.
J. Biol. Chem.279:13934-13943(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH JAKMIP1

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